Chronopharmacological studies of ketamine in normal and NMDA e1 receptor knockout mice
نویسندگان
چکیده
Results. The effect of ketamine had a de®nite daily variation in wild-type mice. No signi®cant difference in blood concentration was observed at different dosing times (10:00 and 22:00). In NMDA receptor e1 KO mice, the hypnotic effect of ketamine was weaker than in wild-type mice and there was no dependence on the time of administration. Signi®cant pharmacokinetic differences were not observed between wild-type and KO mice.
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